近日，科睿唯安公布了2026年度“引文桂冠奖”(Citation Laureates) 获奖名单。来自7个国家的22位杰出科学家获奖，其中16位获奖者任职于美国，加拿大、丹麦、以色列、日本、中国、瑞士各有1人。引文桂冠奖由科睿唯安科学信息研究所 (ISI) 专家团队评选，旨在表彰作出开创性贡献，塑造科学与社会未来的科学家。他们的研究成果具有诺贝尔奖级别的影响力。
在本年度获奖者中，共有8位科学家曾在MDPI期刊发表研究成果。在此，我们谨向所有获奖者表示衷心的祝贺。
生理学或医学领域
Jens Juul Holst
丹麦哥本哈根大学帕努姆研究所生物医学系医学生理学教授、诺和诺德基础代谢研究中心资深课题组负责人
获奖理由：发现并鉴定胰高血糖素样肽-1（GLP-1），系统阐明其生物活性机制
相关文章
Bornæs, O.; Nielsen, R.L.; Christensen, L.W.S.; Storgaard, I.K.; Kallemose, T.; Juul-Larsen, H.G.; Tavenier, J.; Jawad, B.; Andersen, O.; Holst, J.J.; et al. Effects of Sativex® Versus Placebo on Glucagon-like Peptide-1, Total Ghrelin, and Subjective Appetite in Older Adults with Poor Appetite: A Protocolized Secondary Analysis of a Double-Blind, Randomized, Placebo-Controlled Crossover Trial. Nutrients 2026, 18, 2274.
点击下方链接，阅读英文全文
https://www.mdpi.com/2072-6643/18/14/2274
Abba, V.; Nielsen, A.B.E.; Buhr, P.; Hammelev, K.P.; Holst, J.J.; Lobato, C.B. Effects of Preceding Anesthesia Protocols on Insulin and Glucagon Secretion from Isolated Perfused Rat Pancreas Preparations. Anesth. Res. 2026, 3, 6.
点击下方链接，阅读英文全文
https://www.mdpi.com/2813-5806/3/1/6
McCarthy, O.M.; Kristensen, K.B.; Ranjan, A.G.; Nicholas, C.; Holst, J.J.; Bracken, R.M.; Nørgaard, K.; Schmidt, S. Influence of Diets Differing in Macronutrient Composition on Metabolic Regulation During Exercise in Adults with Type 1 Diabetes. Nutrients 2025, 17, 3637.
点击下方链接，阅读英文全文
https://www.mdpi.com/2072-6643/17/23/3637
Lansbury, E.L.; Vana, V.; Lund, M.L.; Ludwig, M.Q.; Mamedova, E.; Gautron, L.; Arnold, M.; Egerod, K.L.; Kuhre, R.E.; Holst, J.J.; et al. Neurons Co-Expressing GLP-1, CCK, and PYY Receptors Particularly in Right Nodose Ganglion and Innervating Entire GI Tract in Mice. Int. J. Mol. Sci. 2025, 26, 2053.
点击下方链接，阅读英文全文
https://www.mdpi.com/1422-0067/26/5/2053
McCarthy, O.M.; Christensen, M.B.; Tawfik, S.; Kristensen, K.B.; Hartmann, B.; Holst, J.J.; Schmidt, S.; Nørgaard, K.; Bracken, R.M. Metabolic and Hormonal Responses to Isomaltulose Ingestion Before or During Sustained Submaximal Exercise in Adults with Type 1 Diabetes Using Automated Insulin Delivery Systems. Nutrients 2024, 16, 4098.
点击下方链接，阅读英文全文
https://www.mdpi.com/2072-6643/16/23/4098
Hunt, J.E.; Christiansen, C.B.; Yassin, M.; Hartmann, B.; Offermanns, S.; Dragsted, L.O.; Holst, J.J.; Kissow, H. The Severity of DSS-Induced Colitis Is Independent of the SCFA-FFAR2/3-GLP-1 Pathway Despite SCFAs Inducing GLP-1 Secretion via FFAR2/3. Metabolites 2024, 14, 395.
点击下方链接，阅读英文全文
https://www.mdpi.com/2218-1989/14/7/395
Mantri, A.; Köhlmoos, A.; Schelski, D.S.; Seel, W.; Stoffel-Wagner, B.; Krawitz, P.; Stehle, P.; Holst, J.J.; Weber, B.; Koban, L.; et al. Impact of Synbiotic Intake on Liver Metabolism in Metabolically Healthy Participants and Its Potential Preventive Effect on Metabolic-Dysfunction-Associated Fatty Liver Disease (MAFLD): A Randomized, Placebo-Controlled, Double-Blinded Clinical Trial. Nutrients 2024, 16, 1300.
点击下方链接，阅读英文全文
https://www.mdpi.com/2072-6643/16/9/1300
Madsen, S.; Bak, S.Y.; Yde, C.C.; Jensen, H.M.; Knudsen, T.A.; Bæch-Laursen, C.; Holst, J.J.; Laustsen, C.; Hedemann, M.S. Unravelling Effects of Rosemary (Rosmarinus officinalis L.) Extract on Hepatic Fat Accumulation and Plasma Lipid Profile in Rats Fed a High-Fat Western-Style Diet. Metabolites 2023, 13, 974.
点击下方链接，阅读英文全文
https://www.mdpi.com/2218-1989/13/9/974
Weber, P.; Thomsen, M.N.; Skytte, M.J.; Samkani, A.; Carl, M.H.; Astrup, A.; Frystyk, J.; Holst, J.J.; Hartmann, B.; Madsbad, S.; et al. Effects of Carbohydrate Restriction on Body Weight and Glycemic Control in Individuals with Type 2 Diabetes: A Randomized Controlled Trial of Efficacy in Real-Life Settings. Nutrients 2022, 14, 5244.
点击下方链接，阅读英文全文
https://www.mdpi.com/2072-6643/14/24/5244
Damgaard, M.V.; Jepsen, S.L.; Ashcroft, S.P.; Holst, J.J.; Treebak, J.T. Pterostilbene Fails to Rescue Insulin Secretion and Sensitivity in Multiple Murine Models of Diabetes. Nutrients 2022, 14, 3741.
点击下方链接，阅读英文全文
https://www.mdpi.com/2072-6643/14/18/3741
Hjørne, A.P.; Modvig, I.M.; Holst, J.J. The Sensory Mechanisms of Nutrient-Induced GLP-1 Secretion. Metabolites 2022, 12, 420.
点击下方链接，阅读英文全文
https://www.mdpi.com/2218-1989/12/5/420
Han, X.X.; Holst, J.J.; Galbo, H. Studies in Rats of Combined Muscle and Liver Perfusion and of Muscle Extract Indicate That Contractions Release a Muscle Hormone Directly Enhancing Hepatic Glycogenolysis. J. Pers. Med. 2022, 12, 837.
点击下方链接，阅读英文全文
https://www.mdpi.com/2075-4426/12/5/837
Alzahrani, A.H.; Skytte, M.J.; Samkani, A.; Thomsen, M.N.; Astrup, A.; Ritz, C.; Frystyk, J.; Holst, J.J.; Madsbad, S.; Haugaard, S.B.; et al. Effects of a Self-Prepared Carbohydrate-Reduced High-Protein Diet on Cardiovascular Disease Risk Markers in Patients with Type 2 Diabetes. Nutrients 2021, 13, 1694.
点击下方链接，阅读英文全文
https://www.mdpi.com/2072-6643/13/5/1694
Hunt, J.E.; Holst, J.J.; Jeppesen, P.B.; Kissow, H. GLP-1 and Intestinal Diseases. Biomedicines 2021, 9, 383.
点击下方链接，阅读英文全文
https://www.mdpi.com/2227-9059/9/4/383
Mohr, A.E.; Minicucci, O.; Long, D., Jr.; Miller, V.J.; Keller, A.; Sheridan, C.; O’brien, G.; Ward, E.; Schuler, B.; Connelly, S.; et al. Resistant Starch Combined with Whey Protein Increases Postprandial Metabolism and Lowers Glucose and Insulin Responses in Healthy Adult Men. Foods 2021, 10, 537.
点击下方链接，阅读英文全文
https://www.mdpi.com/2304-8158/10/3/537
Meyer-Gerspach, A.C.; Drewe, J.; Verbeure, W.; Roux, C.W.l.; Dellatorre-Teixeira, L.; Rehfeld, J.F.; Holst, J.J.; Hartmann, B.; Tack, J.; Peterli, R.; et al. Effect of the Natural Sweetener Xylitol on Gut Hormone Secretion and Gastric Emptying in Humans: A Pilot Dose-Ranging Study. Nutrients 2021, 13, 174.
点击下方链接，阅读英文全文
https://www.mdpi.com/2072-6643/13/1/174
Boer, G.A.; Holst, J.J. Incretin Hormones and Type 2 Diabetes—Mechanistic Insights and Therapeutic Approaches. Biology 2020, 9, 473.
点击下方链接，阅读英文全文
https://www.mdpi.com/2079-7737/9/12/473
Billeschou, A.; Hunt, J.E.; Ghimire, A.; Holst, J.J.; Kissow, H. Intestinal Adaptation upon Chemotherapy-Induced Intestinal Injury in Mice Depends on GLP-2 Receptor Activation. Biomedicines 2021, 9, 46.
点击下方链接，阅读英文全文
https://www.mdpi.com/2227-9059/9/1/46
Crabtree, D.R.; Buosi, W.; Fyfe, C.L.; Horgan, G.W.; Manios, Y.; Androutsos, O.; Giannopoulou, A.; Finlayson, G.; Beaulieu, K.; Meek, C.L.; et al. Appetite Control across the Lifecourse: The Acute Impact of Breakfast Drink Quantity and Protein Content. The Full4Health Project. Nutrients 2020, 12, 3710.
点击下方链接，阅读英文全文
https://www.mdpi.com/2072-6643/12/12/3710
Vedtofte, L.; Bahne, E.; Foghsgaard, S.; Bagger, J.I.; Andreasen, C.; Strandberg, C.; Gørtz, P.M.; Holst, J.J.; Grønbæk, H.; Svare, J.A.; et al. One Year’s Treatment with the Glucagon-Like Peptide 1 Receptor Agonist Liraglutide Decreases Hepatic Fat Content in Women with Nonalcoholic Fatty Liver Disease and Prior Gestational Diabetes Mellitus in a Randomized, Placebo-Controlled Trial. J. Clin. Med. 2020, 9, 3213.
点击下方链接，阅读英文全文
https://www.mdpi.com/2077-0383/9/10/3213
Trammell, S.A.J.; Svenningsen, J.S.; Holst, J.J.; Gillum, M.P.; Kuhre, R.E. Hepatic Bile Acid Reuptake in the Rat Depends on Bile Acid Conjugation but Not on Agonistic Properties towards FXR and TGR5. Molecules 2020, 25, 2371.
点击下方链接，阅读英文全文
https://www.mdpi.com/1420-3049/25/10/2371
Holst, J.J.; Wewer Albrechtsen, N.J. Methods and Guidelines for Measurement of Glucagon in Plasma. Int. J. Mol. Sci. 2019, 20, 5416.
点击下方链接，阅读英文全文
https://www.mdpi.com/1422-0067/20/21/5416
Tischmann, L.; Drummen, M.; Gatta-Cherifi, B.; Raben, A.; Fogelholm, M.; Hartmann, B.; Holst, J.J.; Matias, I.; Cota, D.; Mensink, R.P.; et al. Effects of a High-Protein/Moderate-Carbohydrate Diet on Appetite, Gut Peptides, and Endocannabinoids—A Preview Study. Nutrients 2019, 11, 2269.
点击下方链接，阅读英文全文
https://www.mdpi.com/2072-6643/11/10/2269
Janah, L.; Kjeldsen, S.; Galsgaard, K.D.; Winther-Sørensen, M.; Stojanovska, E.; Pedersen, J.; Knop, F.K.; Holst, J.J.; Wewer Albrechtsen, N.J. Glucagon Receptor Signaling and Glucagon Resistance. Int. J. Mol. Sci. 2019, 20, 3314.
点击下方链接，阅读英文全文
https://www.mdpi.com/1422-0067/20/13/3314
Samkani, A.; Skytte, M.J.; Thomsen, M.N.; Astrup, A.; Deacon, C.F.; Holst, J.J.; Madsbad, S.; Rehfeld, J.F.; Krarup, T.; Haugaard, S.B. Acute Effects of Dietary Carbohydrate Restriction on Glycemia, Lipemia and Appetite Regulating Hormones in Normal-Weight to Obese Subjects. Nutrients 2018, 10, 1285.
点击下方链接，阅读英文全文
https://www.mdpi.com/2072-6643/10/9/1285
Bjørnshave, A.; Hermansen, K.; Holst, J.J. Pre-Meal Effect of Whey Proteins on Metabolic Parameters in Subjects with and without Type 2 Diabetes: A Randomized, Crossover Trial. Nutrients 2018, 10, 122.
点击下方链接，阅读英文全文
https://www.mdpi.com/2072-6643/10/2/122
Saltiel, M.Y.; Kuhre, R.E.; Christiansen, C.B.; Eliasen, R.; Conde-Frieboes, K.W.; Rosenkilde, M.M.; Holst, J.J. Sweet Taste Receptor Activation in the Gut Is of Limited Importance for Glucose-Stimulated GLP-1 and GIP Secretion. Nutrients 2017, 9, 418.
点击下方链接，阅读英文全文
https://www.mdpi.com/2072-6643/9/4/418
Samocha-Bonet, D.; Chisholm, D.J.; Holst, J.J.; Greenfield, J.R. L-Glutamine and Whole Protein Restore First-Phase Insulin Response and Increase Glucagon-Like Peptide-1 in Type 2 Diabetes Patients. Nutrients 2015, 7, 2101-2108.
点击下方链接，阅读英文全文
https://www.mdpi.com/2072-6643/7/4/2101
James G. Fujimoto
美国麻省理工学院电子学研究实验室、电子工程与计算机科学系电子工程Elihu Thomson 讲席教授
黄大卫
凯西眼科研究所研究主任、副所长；Wold 家族眼科成像冠名讲席教授；美国俄勒冈健康与科学大学眼科学与生物医学工程教授；眼科光学与激光中心 (COOL 实验室) 主任
获奖理由：研发光学相干断层扫描（OCT）这一新型成像技术，为医学、生物医学研究及其他领域开辟全新成像手段
相关文章
Wang, Z.; Lee, H.-C.; Ahsen, O.O.; Liang, K.; Figueiredo, M.; Huang, Q.; Fujimoto, J.G.; Mashimo, H. Computer-Aided Analysis of Gland-Like Subsurface Hyposcattering Structures in Barrett’s Esophagus Using Optical Coherence Tomography. Appl. Sci. 2018, 8, 2420.
点击下方链接，阅读英文全文
https://www.mdpi.com/2076-3417/8/12/2420
Tsai, T.-H.; Fujimoto, J.G.; Mashimo, H. Endoscopic Optical Coherence Tomography for Clinical Gastroenterology. Diagnostics 2014, 4, 57-93.
点击下方链接，阅读英文全文
https://www.mdpi.com/2075-4418/4/2/57
de Souza, R.G.; Huang, D.; Prahl, S.; Nakhleh, L.; Pflugfelder, S.C. Comparison of Efficacy and Inflammatory Response to Thermoconjunctivoplasty Performed with Cautery or Pulsed 1460 nm Laser. Int. J. Mol. Sci. 2023, 24, 5740.
点击下方链接，阅读英文全文
https://www.mdpi.com/1422-0067/24/6/5740
物理学领域
安达千波矢
日本九州大学杰出教授，有机光电子研究中心（OPERA）主任
Mark E. Thompson
美国南加州大学化学、化学工程与材料科学大学教授
获奖理由：在磷光有机发光二极管（PHOLED）和热激活延迟荧光（TADF）方面的开创性研究，推动了超高效率有机发光二极管技术的发展和应用
相关文章
Choi, M.G.; Lee, C.H.; Adachi, C.; Lee, S.Y. Highly Effective Thermally Activated Delayed Fluorescence Emitters Based on Symmetry and Asymmetry Nicotinonitrile Derivatives. Molecules 2022, 27, 8274.
点击下方链接，阅读英文全文
https://www.mdpi.com/1420-3049/27/23/8274
Wei, W.; Ma, J.; Schaab, J.; Brooks, J.; Kang, S.; Whited, M.T.; Djurovich, P.I.; Thompson, M.E. A Comparison between Triphenylmethyl and Triphenylsilyl Spirobifluorenyl Hosts: Synthesis, Photophysics and Performance in Phosphorescent Organic Light-Emitting Diodes. Molecules 2023, 28, 5241.
点击下方链接，阅读英文全文
https://www.mdpi.com/1420-3049/28/13/5241
化学领域
Harry B. Gray
美国加州理工学院 Arnold O. Beckman 化学讲席教授
Jay R. Winkler
美国加州理工学院贝克曼研究所成员、化学系关联研究员
获奖理由：深化对蛋白质长程电子转移机制的认知
相关文章
Hunter, B.M.; Winkler, J.R.; Gray, H.B. Iron Is the Active Site in Nickel/Iron Water Oxidation Electrocatalysts. Molecules 2018, 23, 903.
点击下方链接，阅读英文全文
https://www.mdpi.com/1420-3049/23/4/903
刘如谦
美国哈佛大学自然科学 Thomas Dudley Cabot 讲席教授、布罗德研究所 Richard Merkin 讲席教授、霍华德·休斯医学研究所研究员
获奖理由：开发出碱基编辑和先导编辑等精准基因编辑技术，可在活体系统中对 DNA进行直接编辑，推动生命科学领域的革新，使挽救生命的可编程药物成为可能
相关文章
Olaghere, J.; Williams, D.A.; Farrar, J.; Büning, H.; Calhoun, C.; Ho, T.; Inamdar, M.S.; Liu, D.; Makani, J.; Nyarko, K.; et al. Scientific Advancements in Gene Therapies: Opportunities for Global Regulatory Convergence. Biomedicines 2025, 13, 758.
点击下方链接，阅读英文全文
https://www.mdpi.com/2227-9059/13/3/758
Daliri, K.; Hescheler, J.; Newby, G.A.; Clement, K.; Liu, D.R.; Pfannkuche, K. Modulating Collagen I Expression in Fibroblasts by CRISPR-Cas9 Base Editing of the Collagen 1A1 Promoter. Int. J. Mol. Sci. 2025, 26, 3041.
点击下方链接，阅读英文全文